Why does nephrotic syndrome cause hypercoagulability

In all cases the risk of hemorrhage should be weighed heavily against the potential benefits of anticoagulation. Jennifer Mulliken makes a reasonable argument for individualizing the decision to anticoagulate, as there are no appropriate trials comparing conservative management with anticoagulation.

Unfortunately, individualization is not very easy when there are no good markers of high risk and there is no good evidence of the effect of anticoagulation in renal vein thrombosis. Orth SR, Ritz E. The nephrotic syndrome. N Engl J Med. High absolute risks and predictors of venous and arterial thromboembolic events in patients with nephrotic syndrome: results from a large retrospective cohort study. A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism.

Arch Intern Med. Incidence, prevalence and mortality of cardiovascular diseases in the United States. The clinical spectrum of renal vein thrombosis: acute and chronic. Am J Med. Renal vein thrombosis in nephrotic syndrome — a prospective study and review. Postgrad Med J. Clinical correlation between hypercoagulability and thrombo-embolic phenomena. Kidney Int. By Jennifer Mulliken Faculty Peer Reviewed Case 1: A year-old African-American male with a history of bilateral pulmonary emboli presents with a 1-week history of bilateral lower extremity edema.

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Save your search. Customize your interests. Create a personal account or sign in to:. Raven Press, New York, pp — Handley D, Lawrence D F. IX deficiency in the nephrotic syndrome. J Pediatr — Thromb Res — Joshida N, Aoki N Release of arachidonic acid from human platelets. A key role for the potentiation of platelet aggregability in normal subjects as well as in those with nephrotic syndrome. Blood — Thromb Diath Haem — Arch Int Med — Marsh J, Drabkin D Experimental reconstruction of metabolic pattern of lipid nephrotis: key role of hepatic protein synthesis in hyperlipemia.

Metabolism — Muus P, Bonta I, Den Oudsten S Plasma levels of malondialdehyde, a product of cyclooxygenase dependent and independent lipid peroxidation in rheumatoid arthritis. Prostaglandins — Proc EDTA — J Biol Chem — Takeda Y, Chen A Fibrinogen metabolism and distribution in patients with the nephrotic syndrome. Hemostasis — FK Schattauer, Stuttgart, S — Medicine Baltimore — Download references.

You can also search for this author in PubMed Google Scholar. Reprints and Permissions. Andrassy, K. Hypercoagulability in the nephrotic syndrome. Klin Wochenschr 58, —